E. Bülbring and H. Kuriyama “Effect of changes in ionic environment on the action of acetylcholine and adrenaline on the smooth muscle cells of guinea-pig taenia coli,” J. Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli, Proceedings of the Royal Society of London. The Adrenaline affect the lungs significantly. AND T. TOMITA The effect of cold storage on the adrenergic mechanisms of intestinal smooth muscle. In solution of higher concentration of K, adrenaline caused the relaxation again.
4. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. prenaline, adrenaline, noradrenaline and phenylephrine (Shibata, Hattori & Timmerman, 1970). Identify the lowest concentration of ACh that produced the maximum contractile effect in experiment 1 . Ciba Foundation Symposium ‐ Control of Glycogen Metabolism. Giarman NJ , Reit E Br J Pharmacol Chemother , 29(2):168-180, 01 Feb 1967 [65] Inde … 3 A shows the effects of adrenaline (10-7 and 10-6 g/ml) on the membrane activity of arterial smooth muscle in hypertonic Krebs solution. Learn more. Biological Sciences, 10.1098/rspb.1969.0015, 172 , 1027, (121-136), (1969). b, In smooth muscle surrounding the bronchioles, PKA phosphorylates a protein (MLCK) needed for contraction, inactivating it. Article/chapter can be printed. Notice of renewal procedure of Institution authentication service. Biology 304 Smooth Muscle Lab Smooth muscle can be found in a wide range of organs. Roy. on intestinal smooth muscle indirectly through an effect on the ENS (4). Article/chapter can be downloaded. Determine how much of each stock solution is required to create this concentration in the organ bath, taking into account that the calculations used to create Table … 12, 413–416 (1998) CRINUM GLAUCUM ON INTESTINAL SMOOTH MUSCLE 415 Figure 3. Lond. The Tohoku Journal of Experimental Medicine 77(4), 334-339, 1962, Adrenaline Reversal in Intestinal Smooth Muscle, Department of Applied Physiology, Tohoku University, School of Medicine, The Tohoku Journal of Experimental Medicine. If you do not receive an email within 10 minutes, your email address may not be registered, Rabbit intestine is a smooth muscle which shows regular pendular movement (i.e. The electrophysiological basis of the motor inhibitory effect of adrenaline on rabbit small intestinal smooth muscle. If you have previously obtained access with your personal account, please log in. Please check your email for instructions on resetting your password. continuous contraction and relaxation). Abdominal Aortic Diameter Is Increased in Males with a Family History of Abdominal Aortic Aneurysms: Results from the Danish VIVA-trial Google Scholar We now report the effect of two new /3-adrenoceptor blocking agents, MK 950* and alprenolol, on the action of adrenaline … (1961), 156, pp. Mechanical and intracellular electrical activity were recorded simultaneously from small intestinal smooth muscle of the dog. Soc. Adrenaline is a nonselective agonist of all adrenergic receptors, including the major subtypes α 1 , α 2 , β 1 , β 2 , and β 3 . Now, this speed up the respiration process. Series B. (2) The hyperpolarization and stabilization of the Proc. Electrophysiological studies have been made of the inhibitory effects of dopamine and adrenaline on motor activity of the stomach and intestine in the plaice Platessa platessa. Isolated smooth muscle strip from rabbit intestine was used for measuring the isometric tension to observe the effect of adrenaline on the depolarized smooth muscle.
2. The spontaneous electrical activity of small intestinal smooth muscle cells consists of repetive depolarizations (control activity) on which spikes (response activity) may be superimposed; each spike is preceded by a prepotential. J. Phy8iol. FYI only: For smooth muscle to contract, an active kinase (MLCK) must bind Ca ++ (in the form of a calmodulin /Ca ++ complex). [Ser. Similar stimulant action of adrenaline was observed in muscle strip which has been immersed in NaBr-, TEACl-, LiCl- or choline-Krebs solutions.
5. J Physiol. Scientists found that (1) The effect of calcium, barium and manganese on membrane conductance and spike activity of intestinal smooth muscle, and their influence on the action of adrenaline, was studied. Tonic and phasic contractions due to exogenous acetylcholine and elevated external K+ concentration were (2) The hyperpolarization and stabilization of the membrane by exposure to excess Ca was associated with a decrease of membrane resistance. Bath contained tyrod Under normal condition, adrenaline causes the relaxation, but by increasing the concentration of K in Krebs solution, this relaxing effect became gradually less, until the effect of adrenaline was reverse. For this purpose, 1-2 cm of Newzeland rabbit’s uterus (1300-2300 g) was mounted in organ bath. It is suggested from these results that, as far as mechanical response of smooth muscle is concerned, adrenaline has a single action and the direction of response to adrenaline is determined by the functional condition of the muscle cell membrane.
This work was aided by the Grant (GA BMR 5693) from the Rockefeller Foundation to one of the authors (T. Suzuki). This reversal was obtained only in a narrow range of K concentration.
3. As shown in Fig. Intestinal smooth muscle contracts rhythmically in the absence of nerve and hormonal stimulation because of the activity of pacemaker cells between and within the muscle layers. Use the link below to share a full-text version of this article with your friends and colleagues. For instance, if the tone is relatively high, then epinephrine promotes relaxation; however, if the initial smooth muscle tone is lower, contraction is more likely. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. 357-374 357 With 10 text-ftigure8 Printedin Great Britain THE INHIBITORY ACTION OF ADRENALINE ON INTESTINAL SMOOTH MUSCLE IN RELATION TO ITS ACTION ON PHOSPHORYLASE ACTIVITY 1. Reduction of the external Ca … Therefore, to study the effect of drugs on intestinal movement rabbit intestine is ideal preparation. Therefore contraction cannot occur. The physiological effect observed depends on the steady-state existing smooth muscle tone. These organs tend to be tubular, soft tissue organs designed for transporting stuff.Stuff can be blood, air, sperm, food, lymph, babies, venom etc. Res. An effect of histamine on the nictitating membrane of the cat: potentiation of the actions of adrenaline, noradrenaline and acetylcholine. Contraction of the rat isolated colon by adrenaline After /3-adrenoceptor blockade with oxprenolol, adrenaline or noradrenaline contracted the rat isolated colon, and also human and rabbit taeniae coli (Gagnon, 1970; Gagnon & Belisle, 1970; Belisle & Gagnon, 1971). B. and you may need to create a new Wiley Online Library account. R. Soc. Proc. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. Learn about our remote access options, Department of Pathobiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore. Therefore contraction cannot occur. This hormone causes smooth muscle to relax, and as the lungs have smooth Muscle, so, it influences them as well. Aim of this study is to evaluate effect of Barium Chloride on muscle contractility of isolated uterus of rabbit. BULBRING E. Changes in configuration of spontaneously discharged spike potentials from smooth muscle of the guinea-pig's taenia coli; the effect of electrotonic currents and of adrenaline, acetylcholine and histamine. (1) The effect of calcium, barium and manganese on membrane conductance and spike activity of intestinal smooth muscle, and their influence on the action of adrenaline, was studied. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, https://doi.org/10.1002/9780470719343.ch17. 3 A, 10-7g/ml 96 Isolated smooth muscle strip from rabbit intestine was used for measuring the isometric tension to observe the effect of adrenaline on the depolarized smooth muscle.
2. Effects of different concentrations of Crinum glaucum Effects of different concentrations of Crinum glaucum aqueous extract (0.125± 2 mg/mL) and verapamil (10ÿ8 ±10ÿ6M) on potassium chloride induced contraction in the guinea-pig taenia coli. Experiment 2: effect of epinephrine on intestinal smooth muscle contraction. Working off-campus? This effect revealed itself in suppression of peristaltic and tonic contractions of the digestive tract for 2-5 hours. Physiol., 166, 59–74 (1963). Effect of Adrenaline in Hypertonic Krebs Solution Fig. Paulo Boschcov, Antonio C.M. El-Sharkawy, Daniel EE. B] 172, 121–136 (1969c) Google Scholar For example, high levels of adrenaline causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles. (PMID:4656605 PMCID:PMC1666557) Full Text Citations Related Articles Data BioEntities External Links Br J Pharmacol. SOME EFFECTS OF ATP AHD ADEENALINS OA INTESTINAL SMOOTH MUSCLE J. Azelseon, B. Holmberg and G. Hberg Department of Zoophysiology, University of Geborg, Sweden (Received 1 February 1985) Introduction Thin effect of adrenaline may .be related to a stimulation ox metabolic rate ( 3,4,5,6,7, ) either via increased supply of metabolic energy, or the formation of … Name a non-tubular organ that has smooth muscle. Bülbring, E., Tomita, T.: Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli. 172, 121-136 (1969) Printed in Great Britain Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli BY EDITH BULBRING, F.R.S. Paiva, Therezinha B. Paiva, Suma I. Shimuta, Further evidence for the existence of two receptor sites for bradykinin responsible for the diphasic effect in the rat isolated duodenum, British Journal of Pharmacology, 10.1111/j.1476-5381.1984.tb16523.x, 83, 2, (591-600), (2012). Nicotine, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), and electrical transmural stimulation are believed to affect smooth muscle 1.
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4. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. prenaline, adrenaline, noradrenaline and phenylephrine (Shibata, Hattori & Timmerman, 1970). Identify the lowest concentration of ACh that produced the maximum contractile effect in experiment 1 . Ciba Foundation Symposium ‐ Control of Glycogen Metabolism. Giarman NJ , Reit E Br J Pharmacol Chemother , 29(2):168-180, 01 Feb 1967 [65] Inde … 3 A shows the effects of adrenaline (10-7 and 10-6 g/ml) on the membrane activity of arterial smooth muscle in hypertonic Krebs solution. Learn more. Biological Sciences, 10.1098/rspb.1969.0015, 172 , 1027, (121-136), (1969). b, In smooth muscle surrounding the bronchioles, PKA phosphorylates a protein (MLCK) needed for contraction, inactivating it. Article/chapter can be printed. Notice of renewal procedure of Institution authentication service. Biology 304 Smooth Muscle Lab Smooth muscle can be found in a wide range of organs. Roy. on intestinal smooth muscle indirectly through an effect on the ENS (4). Article/chapter can be downloaded. Determine how much of each stock solution is required to create this concentration in the organ bath, taking into account that the calculations used to create Table … 12, 413–416 (1998) CRINUM GLAUCUM ON INTESTINAL SMOOTH MUSCLE 415 Figure 3. Lond. The Tohoku Journal of Experimental Medicine 77(4), 334-339, 1962, Adrenaline Reversal in Intestinal Smooth Muscle, Department of Applied Physiology, Tohoku University, School of Medicine, The Tohoku Journal of Experimental Medicine. If you do not receive an email within 10 minutes, your email address may not be registered, Rabbit intestine is a smooth muscle which shows regular pendular movement (i.e. The electrophysiological basis of the motor inhibitory effect of adrenaline on rabbit small intestinal smooth muscle. If you have previously obtained access with your personal account, please log in. Please check your email for instructions on resetting your password. continuous contraction and relaxation). Abdominal Aortic Diameter Is Increased in Males with a Family History of Abdominal Aortic Aneurysms: Results from the Danish VIVA-trial Google Scholar We now report the effect of two new /3-adrenoceptor blocking agents, MK 950* and alprenolol, on the action of adrenaline … (1961), 156, pp. Mechanical and intracellular electrical activity were recorded simultaneously from small intestinal smooth muscle of the dog. Soc. Adrenaline is a nonselective agonist of all adrenergic receptors, including the major subtypes α 1 , α 2 , β 1 , β 2 , and β 3 . Now, this speed up the respiration process. Series B. (2) The hyperpolarization and stabilization of the Proc. Electrophysiological studies have been made of the inhibitory effects of dopamine and adrenaline on motor activity of the stomach and intestine in the plaice Platessa platessa. Isolated smooth muscle strip from rabbit intestine was used for measuring the isometric tension to observe the effect of adrenaline on the depolarized smooth muscle.
2. The spontaneous electrical activity of small intestinal smooth muscle cells consists of repetive depolarizations (control activity) on which spikes (response activity) may be superimposed; each spike is preceded by a prepotential. J. Phy8iol. FYI only: For smooth muscle to contract, an active kinase (MLCK) must bind Ca ++ (in the form of a calmodulin /Ca ++ complex). [Ser. Similar stimulant action of adrenaline was observed in muscle strip which has been immersed in NaBr-, TEACl-, LiCl- or choline-Krebs solutions.
5. J Physiol. Scientists found that (1) The effect of calcium, barium and manganese on membrane conductance and spike activity of intestinal smooth muscle, and their influence on the action of adrenaline, was studied. Tonic and phasic contractions due to exogenous acetylcholine and elevated external K+ concentration were (2) The hyperpolarization and stabilization of the membrane by exposure to excess Ca was associated with a decrease of membrane resistance. Bath contained tyrod Under normal condition, adrenaline causes the relaxation, but by increasing the concentration of K in Krebs solution, this relaxing effect became gradually less, until the effect of adrenaline was reverse. For this purpose, 1-2 cm of Newzeland rabbit’s uterus (1300-2300 g) was mounted in organ bath. It is suggested from these results that, as far as mechanical response of smooth muscle is concerned, adrenaline has a single action and the direction of response to adrenaline is determined by the functional condition of the muscle cell membrane.
This work was aided by the Grant (GA BMR 5693) from the Rockefeller Foundation to one of the authors (T. Suzuki). This reversal was obtained only in a narrow range of K concentration.
3. As shown in Fig. Intestinal smooth muscle contracts rhythmically in the absence of nerve and hormonal stimulation because of the activity of pacemaker cells between and within the muscle layers. Use the link below to share a full-text version of this article with your friends and colleagues. For instance, if the tone is relatively high, then epinephrine promotes relaxation; however, if the initial smooth muscle tone is lower, contraction is more likely. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. 357-374 357 With 10 text-ftigure8 Printedin Great Britain THE INHIBITORY ACTION OF ADRENALINE ON INTESTINAL SMOOTH MUSCLE IN RELATION TO ITS ACTION ON PHOSPHORYLASE ACTIVITY 1. Reduction of the external Ca … Therefore, to study the effect of drugs on intestinal movement rabbit intestine is ideal preparation. Therefore contraction cannot occur. The physiological effect observed depends on the steady-state existing smooth muscle tone. These organs tend to be tubular, soft tissue organs designed for transporting stuff.Stuff can be blood, air, sperm, food, lymph, babies, venom etc. Res. An effect of histamine on the nictitating membrane of the cat: potentiation of the actions of adrenaline, noradrenaline and acetylcholine. Contraction of the rat isolated colon by adrenaline After /3-adrenoceptor blockade with oxprenolol, adrenaline or noradrenaline contracted the rat isolated colon, and also human and rabbit taeniae coli (Gagnon, 1970; Gagnon & Belisle, 1970; Belisle & Gagnon, 1971). B. and you may need to create a new Wiley Online Library account. R. Soc. Proc. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. Learn about our remote access options, Department of Pathobiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore. Therefore contraction cannot occur. This hormone causes smooth muscle to relax, and as the lungs have smooth Muscle, so, it influences them as well. Aim of this study is to evaluate effect of Barium Chloride on muscle contractility of isolated uterus of rabbit. BULBRING E. Changes in configuration of spontaneously discharged spike potentials from smooth muscle of the guinea-pig's taenia coli; the effect of electrotonic currents and of adrenaline, acetylcholine and histamine. (1) The effect of calcium, barium and manganese on membrane conductance and spike activity of intestinal smooth muscle, and their influence on the action of adrenaline, was studied. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, https://doi.org/10.1002/9780470719343.ch17. 3 A, 10-7g/ml 96 Isolated smooth muscle strip from rabbit intestine was used for measuring the isometric tension to observe the effect of adrenaline on the depolarized smooth muscle.
2. Effects of different concentrations of Crinum glaucum Effects of different concentrations of Crinum glaucum aqueous extract (0.125± 2 mg/mL) and verapamil (10ÿ8 ±10ÿ6M) on potassium chloride induced contraction in the guinea-pig taenia coli. Experiment 2: effect of epinephrine on intestinal smooth muscle contraction. Working off-campus? This effect revealed itself in suppression of peristaltic and tonic contractions of the digestive tract for 2-5 hours. Physiol., 166, 59–74 (1963). Effect of Adrenaline in Hypertonic Krebs Solution Fig. Paulo Boschcov, Antonio C.M. El-Sharkawy, Daniel EE. B] 172, 121–136 (1969c) Google Scholar For example, high levels of adrenaline causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles. (PMID:4656605 PMCID:PMC1666557) Full Text Citations Related Articles Data BioEntities External Links Br J Pharmacol. SOME EFFECTS OF ATP AHD ADEENALINS OA INTESTINAL SMOOTH MUSCLE J. Azelseon, B. Holmberg and G. Hberg Department of Zoophysiology, University of Geborg, Sweden (Received 1 February 1985) Introduction Thin effect of adrenaline may .be related to a stimulation ox metabolic rate ( 3,4,5,6,7, ) either via increased supply of metabolic energy, or the formation of … Name a non-tubular organ that has smooth muscle. Bülbring, E., Tomita, T.: Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli. 172, 121-136 (1969) Printed in Great Britain Effect of calcium, barium and manganese on the action of adrenaline in the smooth muscle of the guinea-pig taenia coli BY EDITH BULBRING, F.R.S. Paiva, Therezinha B. Paiva, Suma I. Shimuta, Further evidence for the existence of two receptor sites for bradykinin responsible for the diphasic effect in the rat isolated duodenum, British Journal of Pharmacology, 10.1111/j.1476-5381.1984.tb16523.x, 83, 2, (591-600), (2012). Nicotine, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), and electrical transmural stimulation are believed to affect smooth muscle 1.
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